| Single, glycosylated 37kDa polypeptide containing 299 amino acids |
| Encoded by a four exon gene (3.6 kb) located on the long arm of chromosome 19 |
| Three major isoforms E2, E3, E4 |
| Isoforms are expressed from multiple alleles at a single Apo E genetic locus |
| Three common homozygous (2/2, 3/3, 4/4) and heterozygous (2/3, 2/4, 3/4) phenotypes |
| Primarily functions in cholesterol transport with an affinity of binding to the LDL receptor of E4>> |
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